Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy

Nasser A M Yehia; Walfrido Antuch; Barbara Beck; Sibylle Hess; Vesna Schauer-Vukasinović; Michael Almstetter; Patrick Furer; Eberhardt Herdtweck; Alexander Dömling

doi:10.1016/j.bmcl.2004.04.026

Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3121-5. doi: 10.1016/j.bmcl.2004.04.026.

Authors

Nasser A M Yehia¹, Walfrido Antuch, Barbara Beck, Sibylle Hess, Vesna Schauer-Vukasinović, Michael Almstetter, Patrick Furer, Eberhardt Herdtweck, Alexander Dömling

Affiliation

¹ Morphochem AG, Gmunderstr--37-37a, 81379 München, Germany.

PMID: 15149657
DOI: 10.1016/j.bmcl.2004.04.026

Abstract

Using a newly developed multicomponent chemistry strategy in combination with structure based drug design, a new class of HIV-1 protease inhibitors has been obtained.

MeSH terms

Binding Sites / physiology
Chemistry, Pharmaceutical / methods*
HIV Protease / metabolism*
HIV Protease Inhibitors / chemical synthesis*
HIV Protease Inhibitors / metabolism*
HIV Protease Inhibitors / pharmacology

Substances

HIV Protease Inhibitors
HIV Protease